Description

2-Propanesulfinamide, n-[(R)-[2-[Bis(1,1-Dimethylethyl)Phosphino]Phenyl]Phenylmethyl]-N,2-Dimethyl-, [S(R)]- is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in modern asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, particularly in the synthesis of complex pharmaceutical intermediates and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric metal-catalyzed reactions, such as hydrogenation, cross-coupling, and allylic substitution.
• Critical component in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) for drug discovery and development.
• Use in the preparation of novel catalysts for the production of agrochemicals and specialty chemicals.
• Research and development of new methodologies in academic and industrial organic chemistry laboratories.
• Building block for creating complex molecular architectures in material science and supramolecular chemistry.

Basic Information

Product Name	2-Propanesulfinamide, n-[(R)-[2-[Bis(1,1-Dimethylethyl)Phosphino]Phenyl]Phenylmethyl]-N,2-Dimethyl-, [S(R)]-
CAS No.	2757083-12-6
Molecular Formula	C26H40NOPS
Molecular Weight	445.63 g/mol
Synonyms	(SR)-N-[(R)-[2-(Di-tert-butylphosphino)phenyl](phenyl)methyl]-N,2-dimethylpropane-2-sulfinamide; (SR)-N-[(R)-[2-(Di-tert-butylphosphino)phenyl](phenyl)methyl]-N,2-dimethyl-2-propanesulfinamide; Chiral Sulfinamide-Phosphine Ligand; tert-ButylPHOS Sulfinamide Ligand; Asymmetric Hybrid Ligand; (R)-[2-(Di-tert-butylphosphino)phenyl](phenyl)methyl (SR)-N,2-dimethylpropane-2-sulfinamide
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure the highest standards of purity and enantiomeric excess (ee) required for sensitive asymmetric synthesis. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (by HPLC/NMR), chiral purity, and other critical parameters. Our quality systems support development from research to commercial scale under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.