Description

2-Propanesulfinamide, n-[(R)-[5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Phenylmethyl]-N,2-Dimethyl-, [S(R)]- is a sophisticated chiral sulfinamide ligand, specifically designed for asymmetric synthesis and catalysis. This compound matters for its pivotal role in enabling highly enantioselective transformations, crucial for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical R&D laboratories and advanced chemical synthesis facilities need this high-value ligand to achieve superior stereochemical control in critical bond-forming reactions.

Application

• As a chiral ligand in asymmetric metal-catalyzed reactions, such as hydrogenation, allylic substitution, and cross-coupling.
• For the enantioselective synthesis of complex pharmaceutical intermediates and active ingredients.
• In academic and industrial research focused on developing novel catalytic methodologies.
• As a key component in catalyst screening kits for high-throughput experimentation (HTE) in process chemistry.
• For the preparation of specialty fine chemicals and agrochemicals requiring high optical purity.
• In method development and optimization for scale-up to GMP manufacturing.

Basic Information

Product Name	2-Propanesulfinamide, n-[(R)-[5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Phenylmethyl]-N,2-Dimethyl-, [S(R)]-
CAS No.	2757083-09-1
Molecular Formula	C39H38NO2PS
Molecular Weight	615.77 g/mol
Synonyms	(SR)-N-[(R)-[5-(Diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]phenylmethyl]-N,2-dimethyl-2-propanesulfinamide; (SR)-DTBM-SEGPHOS Sulfinamide Ligand; Chiral Xantphos-type Sulfinamide Ligand; Asymmetric Sulfinamide Ligand; SEGPHOS-based Sulfinamide; DTBM-SEGPHOS-Sulfinamide; Chiral Phosphine-Sulfinamide Hybrid Ligand; N-[(R)-[5-(Diphenylphosphino)-9,9-Dimethylxanthen-4-yl](phenyl)methyl]-N,2-dimethylpropane-2-sulfinamide
EINECS	Contact for details

Quality Control

Our high-purity chiral ligands undergo rigorous quality testing to ensure batch-to-batch consistency and performance in sensitive catalytic applications. Standard analytical techniques including HPLC, NMR, and chiral analysis are employed to verify identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere for long-term stability. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.