Description

Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(2-Methylpropyl)-, (4R)- is a sophisticated chiral organophosphorus-oxazole hybrid ligand, representing a key building block in advanced catalytic systems. Its value lies in its ability to impart high enantioselectivity and activity in transition metal-catalyzed reactions, which is critical for the efficient synthesis of complex chiral molecules. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand for asymmetric hydrogenation, cross-coupling, and C-H activation reactions.
• Pharmaceutical Intermediate Synthesis: Enables the production of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Development: Used in the research and synthesis of novel, stereoselective herbicides, fungicides, and insecticides.
• Fine Chemical Manufacturing: Facilitates the creation of high-value chiral flavors, fragrances, and specialty materials.
• Academic & Industrial Research: A critical tool for developing new catalytic methodologies and exploring novel reaction pathways in organic synthesis.
• Catalyst Library Development: Used by catalyst suppliers to create proprietary, high-performance catalyst kits for screening and optimization.

Basic Information

Item	Details
Product Name	Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(2-Methylpropyl)-, (4R)-
CAS No.	2757082-85-0
Molecular Formula	C29H30NOP
Molecular Weight	439.53 g/mol
Synonyms	(4R)-2-[2-(Diphenylphosphino)phenyl]-4-(isobutyl)-4,5-dihydrooxazole; (R)-2-[2-(Diphenylphosphino)phenyl]-4-isobutyl-4,5-dihydrooxazole; (R)-Isobutyl-PHOX; Chiral Dihydrooxazole Phosphine Ligand; PHOX-type Ligand; P,N-Ligand; Asymmetric Hydrogenation Ligand; Chiral Bidentate Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced under strict quality-controlled conditions to ensure exceptional purity and enantiomeric excess, which are critical for catalytic performance. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to verify identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade its catalytic efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.