Description

Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,5-Diphenyl-, (4R,5S)- is a highly specialized chiral phosphine-oxazole hybrid ligand, a critical component in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the synthesis of complex, single-enantiomer molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for creating advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a fundamental step in pharmaceutical synthesis.
• Cross-Coupling Reactions: Employed in asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to create chiral biaryl structures.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in the development of active pharmaceutical ingredients (APIs) with high optical purity.
• Agrochemical Research: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Production: Facilitates the creation of chiral flavor and fragrance compounds where specific stereoisomers define the sensory profile.
• Academic and Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Catalyst Library Development: Serves as a sophisticated building block for creating novel catalyst systems for screening and optimization.

Basic Information

Product Name	Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,5-Diphenyl-, (4R,5S)-
CAS No.	2757082-54-3
Molecular Formula	C39H30NOP
Molecular Weight	559.64 g/mol
Synonyms	(4R,5S)-2-[2-(Diphenylphosphino)phenyl]-4,5-diphenyl-4,5-dihydrooxazole; (R,S)-PHOX Ligand (variant); Chiral PHOX Ligand; (4R,5S)-PHOX; P,N-Ligand; Chiral Oxazoline-Phosphine Ligand; Asymmetric Hydrogenation Ligand; 2-(2-Diphenylphosphinophenyl)-4,5-dihydro-4,5-diphenyloxazole, (4R,5S)-
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands undergoes rigorous analytical characterization to ensure identity, purity, and enantiomeric excess meet the exacting standards required for asymmetric synthesis. Our quality assurance protocol includes comprehensive testing via NMR, HPLC, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.