Description

Oxazole, 2-[2-Chloro-6-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(1-Methylethyl)-, (4R)- is a sophisticated chiral organophosphorus-oxazole hybrid ligand designed for advanced catalytic applications. This compound matters for its ability to impart high enantioselectivity and activity in transition metal-catalyzed cross-coupling and asymmetric hydrogenation reactions, which are critical for producing high-value intermediates. Pharmaceutical R&D laboratories and fine chemical manufacturers specializing in the synthesis of active pharmaceutical ingredients (APIs) and complex chiral molecules are the primary users of this high-performance ligand.

Application

• Asymmetric Catalysis: As a key chiral ligand for rhodium, iridium, and palladium catalysts in enantioselective hydrogenation and C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Enabling the production of single-enantiomer intermediates for novel drug candidates in therapeutic areas like oncology and CNS disorders.
• Academic & Industrial R&D: Serving as a critical research tool in methodology development for new catalytic transformations in organic chemistry.
• Fine Chemical Manufacturing: Used in the scalable production of specialty chemicals, flavors, and fragrances requiring high optical purity.
• Material Science Precursor: Potential application in the synthesis of chiral functional materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	Oxazole, 2-[2-Chloro-6-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(1-Methylethyl)-, (4R)-
CAS No.	2757082-52-1
Molecular Formula	C24H23ClNOP
Molecular Weight	407.87 g/mol
Synonyms	(4R)-2-[2-Chloro-6-(diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydrooxazole; (R)-2-[2-Chloro-6-(diphenylphosphanyl)phenyl]-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole; (R)-2-(2-Chloro-6-(diphenylphosphino)phenyl)-4-isopropyl-4,5-dihydrooxazole; Chiral Josiphos-type Oxazole Ligand; (R)-Cl-DiPhOx; (R)-2-(2-Chloro-6-(diphenylphosphanyl)phenyl)-4-(1-methylethyl)-4,5-dihydrooxazole; P,N-Ligand 2757082-52-1
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced under strict quality management to ensure exceptional purity and enantiomeric excess (ee) for demanding catalytic applications. Our standard pharmaceutical-grade material undergoes comprehensive analytical characterization, including chiral HPLC, NMR, and elemental analysis. A detailed Certificate of Analysis (COA) confirming identity, purity, and chiral purity is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and moisture-sensitive; therefore, the container should be flushed with inert gas after each opening and stored in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.