Description

L-Glutamine (1-13C) is a stable isotope-labeled analog of the essential amino acid L-Glutamine, where the carbon atom at the 1-position is the 13C isotope. This compound is critical for advanced metabolic research, enabling precise tracking and quantification of glutamine utilization in biological systems through techniques like Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy. It is primarily utilized by researchers and manufacturers in pharmaceutical development, clinical diagnostics, and nutritional science who require high-purity, well-characterized tracers for accurate flux analysis and biomarker discovery.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism, including the TCA cycle and glutaminolysis, in cell cultures, tissues, and whole organisms.
• Drug Discovery & Development: Employed in pharmacokinetic and pharmacodynamic studies to understand drug mechanisms and their impact on amino acid metabolism.
• Clinical Research & Diagnostics: Serves as an internal standard for the accurate quantification of L-Glutamine in biological samples via LC-MS/MS for disease biomarker research.
• Nutritional Science: Applied in studies investigating protein synthesis, immune function, and gut health to trace the metabolic fate of supplemented glutamine.
• Stable Isotope Labeling: A key building block for the synthesis of more complex 13C-labeled peptides, proteins, or other biomolecules.

Basic Information

Product Name	L-Glutamine (1-13C)
CAS No.	2687960-41-2
Molecular Formula	C413CH10N2O3
Molecular Weight	147.13 g/mol (for 13C1 isotopologue)
Synonyms	(2S)-2-Amino-4-carbamoyl[1-13C]butanoic acid; L-Glutamine-1-13C; [1-13C]-L-Glutamine; Glutamine-1-13C; (S)-2,5-Diamino-5-oxo[1-13C]pentanoic acid; L-Gln-1-13C; 13C Labeled L-Glutamine
EINECS	Contact for details

Quality Control

Every batch of our L-Glutamine (1-13C) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity,
with comprehensive testing including HPLC for chemical assay, NMR and MS for isotopic enrichment verification, and specific tests for related substances. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and labeling position
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Isotopic Enrichment (MS)	≥ 99 atom % 13C
Optical Rotation	[α]D20: +6.0° to +8.0° (c=2 in H2O)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.