Description

(S)-3-(1-Oxo-5-(Piperazin-1-Yl)Isoindolin-2-Yl)Piperidine-2,6-Dione Hydrochloride is a high-purity, non-natural amino acid derivative and a key chiral intermediate in modern pharmaceutical synthesis. This compound is valued for its role as a sophisticated building block in the development of targeted therapeutic agents, particularly in oncology and immunology. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and proteolysis-targeting chimeras (PROTACs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel small-molecule drugs, particularly in oncology.
• PROTAC Linker Component: Used in the design and synthesis of Proteolysis-Targeting Chimeras (PROTACs) due to its structural features that can connect E3 ligase ligands to target protein binders.
• Chemical Biology Research: Serves as a valuable tool compound for studying protein-protein interactions and degradation pathways.
• API Synthesis: Employed in the multi-step synthesis of complex active pharmaceutical ingredients requiring a specific (S)-configured stereocenter.
• Process Development: Used by CDMOs for scaling up synthetic routes from laboratory to pilot and commercial production.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(S)-3-(1-Oxo-5-(Piperazin-1-Yl)Isoindolin-2-Yl)Piperidine-2,6-Dione Hydrochloride
CAS No.	2520107-65-5
Molecular Formula	C17H21N5O3 • HCl
Molecular Weight	395.84 g/mol (Free base: 359.38 g/mol)
Synonyms	(S)-3-(5-(Piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride; (S)-Pomalidomide-Piperazine Hydrochloride; (S)-3-(1-Oxo-5-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione HCl; (S)-Pomalidomide Piperazine Analog Hydrochloride; (2S)-3-[5-(Piperazin-1-yl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride; (S)-3-(5-(Piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione monohydrochloride; 2520107-65-5
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency suitable for pharmaceutical R&D and pre-clinical applications. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, LC-MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing chiral purity, assay, related substances, residual solvents, and other critical parameters is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a controlled humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.