Description

[S(R)]-n-[(R)-[2-(Diadamantanphosphino)Phenyl]Phenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide CAS NO 2509201-09-4 is a sophisticated, chiral sulfinamide-phosphine hybrid ligand designed for advanced asymmetric catalysis. This compound matters because it provides exceptional stereoselectivity and reactivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the synthesis of high-value, enantiomerically pure intermediates. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-performance ligand for developing novel active pharmaceutical ingredients (APIs) and complex organic molecules where precise stereochemical control is paramount.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in the synthesis of chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing stereogenic centers in the development of novel APIs, including antiviral, anticancer, and cardiovascular drugs.
• Cross-Coupling Catalysis: Employed in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig aminations to create biaryl and C-N bonds with high enantiopurity.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral allylic compounds, which are valuable building blocks in natural product synthesis.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Process Chemistry: A valuable tool for methodological development in academia and for scaling up enantioselective processes in industrial settings.

Basic Information

Product Name	[S(R)]-n-[(R)-[2-(Diadamantanphosphino)Phenyl]Phenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2509201-09-4
Molecular Formula	C38H48NOPS
Molecular Weight	597.82 g/mol
Synonyms	(S,R)-JosiPhos Sulfinamide Ligand; (S,R)-Sulfinamido JosiPhos; (S,R)-SF-JosiPhos; (S,R)-N-((R)-(2-(Di-tert-butylphosphino)phenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide (adamantyl variant); Chiral Sulfinyl Phosphine Ligand; t-Bu-Sulfinamide JosiPhos Derivative; Asymmetric Hydrogenation Ligand CAS 2509201-09-4
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced under strict quality control to ensure high chemical and chiral purity, critical for reproducible catalytic performance. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess (ee), and impurity profile. Our quality system is designed to support cGMP and ISO standards for customers in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or ambient temperature will degrade its catalytic performance. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.