Description

Uridine 5'-Triphosphate, Ammonium Salt (D8, 97%+) Chemical Purity 90%+ (In Soln) is a high-purity, deuterium-labeled nucleotide essential for advanced biochemical research and diagnostic applications. This compound is critical for metabolic pathway tracing, enzyme kinetics studies, and as a stable internal standard in quantitative mass spectrometry. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic kit manufacturers focused on nucleotide metabolism, RNA synthesis, and biomarker discovery.

Application

• Metabolic Flux Analysis & Tracer Studies: Acts as a deuterium-labeled tracer to investigate the dynamics of pyrimidine metabolism and nucleotide synthesis pathways in cell cultures and in vivo models.
• Mass Spectrometry Internal Standard: Serves as a critical, non-radioactive internal standard for the accurate quantification of endogenous UTP and related nucleotides via LC-MS/MS, ensuring high precision in pharmacokinetic and metabolomic studies.
• Enzymology & Biochemical Assays: Used as a high-purity substrate for studying the activity and kinetics of RNA polymerases, kinases, and other nucleotide-dependent enzymes.
• Diagnostic Reagent Manufacturing: Incorporated into the production of high-sensitivity diagnostic assays and kits for monitoring diseases related to nucleotide metabolism or mitochondrial function.
• Pharmaceutical R&D: Employed in drug discovery programs targeting viral replication (e.g., as a probe for viral polymerase activity) and cancer metabolism.
• Structural Biology (NMR): The deuterium labeling provides advantages in nuclear magnetic resonance (NMR) spectroscopy for studying protein-nucleotide interactions and molecular structures.

Basic Information

Item	Details
Product Name	Uridine 5'-Triphosphate, Ammonium Salt (D8, 97%+) Chemical Purity 90%+ (In Soln)
CAS No.	2483831-69-0
Molecular Formula	C9H8D8N2O15P3 · xNH3
Molecular Weight	Contact for details
Synonyms	UTP-ammonium salt (D8); Deuterated Uridine Triphosphate Ammonium Salt; [D8]-UTP; UTP-d8 ammonium salt; Uridine-5'-triphosphate-d8 triammonium salt; 2',3',5'-Tri-O-acetyluridine-5'-triphosphate ammonium salt (D8); (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrofuran-2-yl trihydrogen triphosphate ammonium salt (D8)
EINECS	Contact for details

Quality Control

Every batch of our Uridine 5'-Triphosphate, Ammonium Salt (D8) is manufactured and tested under strict quality management systems. We guarantee a chemical purity of 90%+ and a deuterium enrichment of 97%+ (atom % D). Identity, purity, and isotopic enrichment are verified by a combination of advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the solution at ≤ -20°C. Avoid repeated freeze-thaw cycles. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to slightly yellow
Identification (NMR)	Conforms to structure
Deuterium Enrichment (MS)	≥ 97 atom % D
Chemical Purity (HPLC)	≥ 90%
pH (in solution)	6.0 - 8.0
Solvent	Water or buffer (Contact for details)
Concentration	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.