Description

L-Valine (2-13C) is a stable isotope-labeled analog of the essential amino acid L-Valine, specifically enriched with carbon-13 at the 2-position. This precise labeling makes it an indispensable tool for advanced metabolic research and analytical method development, providing critical insights into biological pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical sectors for applications requiring high-fidelity isotopic tracing.

Application

• Isotopic Tracer in Metabolic Flux Analysis (MFA): Used to study and quantify intracellular metabolic pathways in microbial, plant, and mammalian systems.
• Internal Standard for Quantitative Mass Spectrometry: Serves as a critical reference standard in LC-MS and GC-MS for the accurate quantification of valine and related metabolites in complex biological samples.
• Proteomics and Biomarker Research: Employed in stable isotope labeling by amino acids in cell culture (SILAC) and other techniques for protein quantification and turnover studies.
• Pharmaceutical Development: Used in the research and development of labeled drug compounds and for conducting absorption, distribution, metabolism, and excretion (ADME) studies.
• Nutritional Science Research: Applied in studies investigating protein metabolism, amino acid requirements, and the metabolic fate of dietary components.
• NMR Spectroscopy: Acts as a substrate for nuclear magnetic resonance (NMR) studies to elucidate molecular structures and dynamics.

Basic Information

Product Name	L-Valine (2-13C)
CAS No.	2483829-91-8
Molecular Formula	C413CH11NO2
Molecular Weight	118.14 g/mol (for 13C1 isotopologue)
Synonyms	(2S)-2-Amino-3-methyl(2-13C)butanoic acid; L-(2-13C)Valine; (S)-2-Amino-3-methyl(2-13C)butyric acid; Valine-2-13C; [2-13C]-L-Valine; 13C-Labeled L-Valine; Stable Isotope-Labeled Valine
EINECS	Contact for details

Quality Control

Every batch of L-Valine (2-13C) is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure high chemical and isotopic purity, critical for sensitive research applications. Certificates of Analysis (COA) detailing specifications such as isotopic enrichment (atom % 13C), chiral purity, and chemical purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	[α]D20: +26° to +30° (c=1 in H2O)
Chiral Purity (HPLC)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.