Description

Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,5-Diphenyl-, (4S,5R)- is a sophisticated chiral organophosphorus-oxazole hybrid ligand, a key building block in advanced asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-isomer pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop efficient and selective synthetic routes.

Application

• Asymmetric Hydrogenation: As a chiral ligand for rhodium, iridium, or ruthenium catalysts in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Asymmetric C-C Bond Formation: Facilitating enantioselective cross-coupling, allylic alkylation, and cycloaddition reactions for constructing complex chiral molecules.
• Pharmaceutical Intermediate Synthesis: Enabling the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Active Ingredient Development: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profile.
• Material Science & OLED Research: Serving as a precursor or ligand in the synthesis of chiral metal-organic complexes for optoelectronic applications.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.

Basic Information

Product Name	Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,5-Diphenyl-, (4S,5R)-
CAS No.	2468233-72-7
Molecular Formula	C39H30NOP
Molecular Weight	559.64 g/mol
Synonyms	(4S,5R)-2-[2-(Diphenylphosphino)phenyl]-4,5-diphenyl-4,5-dihydrooxazole; (S,R)-PHOX Derivative; Chiral Dihydrooxazole Phosphine Ligand; Josiphos-type Oxazole Ligand; P,N-Ligand; Asymmetric Hydrogenation Ligand; 2-(2-Diphenylphosphinophenyl)-4,5-diphenyl-4,5-dihydrooxazole (4S,5R)-
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure consistency and performance in catalytic applications. Standard quality control includes verification of chiral purity (enantiomeric excess) and chemical purity via advanced analytical techniques. Certificates of Analysis (COA) detailing specific parameters such as assay, enantiomeric excess (by chiral HPLC or SFC), and identity (by 1H/31P/13C NMR, IR) are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC/SFC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.