Description

S(R)]-n-[(S)-[2-(Dicyclohexylphosphino)Phenyl](5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a high-value specialty chemical for advanced synthetic chemistry. Its core value lies in enabling highly enantioselective transformations, crucial for the efficient and cost-effective synthesis of complex chiral molecules. This compound is essential for R&D scientists and process chemists in the pharmaceutical and fine chemical industries, where it serves as a critical catalyst component for asymmetric synthesis, including cross-coupling and hydrogenation reactions.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal-catalyzed reactions such as asymmetric hydrogenation, Suzuki-Miyaura cross-coupling, and allylic substitution.
• Pharmaceutical Intermediate Synthesis: Enabling the enantioselective construction of key chiral centers in active pharmaceutical ingredients (APIs) and advanced intermediates.
• Methodology Development: A valuable tool for academic and industrial research in developing new catalytic asymmetric methodologies.
• Fine Chemical Production: Used in the synthesis of high-value agrochemicals, flavors, fragrances, and other specialty chemicals requiring precise stereochemical control.
• Ligand Screening Libraries: A key component in high-throughput screening kits for identifying optimal catalytic systems for challenging transformations.

Basic Information

Product Name	S(R)]-n-[(S)-[2-(Dicyclohexylphosphino)Phenyl](5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2398533-82-7
Molecular Formula	C37H52NOPS
Molecular Weight	581.85 g/mol
Synonyms	(SR)-N-[(S)-[2-(Dicyclohexylphosphino)phenyl](5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Dicyclohexylphosphine Ligand; (SR,S)-DTBM-SEGPHOS Sulfinamide Derivative; Asymmetric Phosphine-Sulfinamide Ligand; CAS 2398533-82-7; (S)-[2-(Dicyclohexylphosphino)phenyl](5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl tert-Butanesulfinamide (SR isomer)
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral ligand adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including Chiral HPLC to confirm enantiomeric excess (ee) and NMR for structural verification and purity assessment. We provide detailed Certificates of Analysis (COA) with each shipment, documenting key specifications to ensure consistency and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The material is sensitive to strong alkali and should be handled in a dry, controlled environment using standard procedures for air-sensitive compounds.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.