Description

2,3-Difluoro-5-Nitrophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected boronic acid building block, enabling precise cross-coupling reactions in complex molecule assembly. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl scaffolds in medicinal chemistry programs.
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly those containing difluorinated and nitrated aromatic systems.
• Agrochemical Synthesis: Employed in creating advanced active ingredients for crop protection products.
• Material Science Research: Acts as a precursor for synthesizing organic electronic materials and functional polymers.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in probe development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries.

Basic Information

Product Name	2,3-Difluoro-5-Nitrophenylboronic Acid Pinacol Ester
CAS No.	2377610-80-3
Molecular Formula	C₁₂H₁₄BF₂NO₄
Molecular Weight	285.06 g/mol
Synonyms	2,3-Difluoro-5-nitrophenylboronic acid pinacol ester; (2,3-Difluoro-5-nitrophenyl)boronic acid pinacol ester; 5-Nitro-2,3-difluorophenylboronic acid pinacol ester; 2-(2,3-Difluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2,3-difluoro-5-nitrophenyl)boronate; B-(2,3-Difluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-Nitrophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.