Description

4-Fluoro-3-(Morpholinomethyl)Phenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in its role as a protected boronic acid, offering enhanced stability and solubility for demanding cross-coupling reactions, particularly in the synthesis of complex pharmaceutical intermediates. This high-purity reagent is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for Suzuki-Miyaura and other palladium-catalyzed couplings.

Application

• Pharmaceutical Intermediate Synthesis: A key precursor in the Suzuki-Miyaura cross-coupling reaction for constructing biaryl and heterobiaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate complex fluorinated aromatic structures.
• Material Science & OLED Development: Serves as a building block for creating advanced organic electronic materials, including charge-transport layers and emissive materials for OLED displays.
• Ligand & Catalyst Design: Employed in the synthesis of novel bidentate or tridentate ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Utilized in the preparation of chemical probes and labeled compounds for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-Fluoro-3-(Morpholinomethyl)Phenylboronic Acid Pinacol Ester
CAS No.	2377610-63-2
Molecular Formula	C₁₇H₂₅BFNO₃
Molecular Weight	321.20 g/mol
Synonyms	4-Fluoro-3-(morpholin-4-ylmethyl)phenylboronic acid pinacol ester; (4-Fluoro-3-((morpholin-4-yl)methyl)phenyl)boronic acid pinacol ester; 2-(4-Fluoro-3-(morpholinomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 4-Fluoro-3-morpholinomethylbenzeneboronic acid pinacol ester; B-[4-Fluoro-3-(morpholin-4-ylmethyl)phenyl]-5,5-dimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(Morpholinomethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are characterized using advanced techniques including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC-MS. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.