Description

5-Bromo-2,3-Difluoro-4-Formylphenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring bromo, difluoro, and formyl substituents on a phenylboronic acid core, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for advanced heterocyclic systems.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoro and bromo groups contribute to biological activity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where its functional groups allow for precise tuning of electronic properties.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands used in transition metal catalysis and asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and sensors for diagnostic and research applications.
• Polymer Chemistry: Can be incorporated into specialty polymers to introduce specific functional handles or modify polymer backbone properties.

Basic Information

Product Name	5-Bromo-2,3-Difluoro-4-Formylphenylboronic Acid
CAS No.	2377610-13-2
Molecular Formula	C7H4BBrF2O3
Molecular Weight	264.82 g/mol
Synonyms	5-Bromo-2,3-difluoro-4-formylbenzeneboronic acid; (5-Bromo-2,3-difluoro-4-formylphenyl)boronic acid; 4-Borono-2-bromo-3,6-difluorobenzaldehyde; 2-Bromo-3,6-difluoro-4-formylphenylboronic acid; B-(5-Bromo-2,3-difluoro-4-formylphenyl)boronic acid; CAS 2377610-13-2
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,3-Difluoro-4-Formylphenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive analytical data including HPLC purity, NMR (1H, 13C, 19F, 11B) confirmation, and elemental analysis. Certificates of Analysis (COA) detailing all specifications are available upon request and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.