Description

(3-{[(Benzyloxy)Carbonyl]Amino}-4,5-Difluorophenyl)Boronic Acid is a sophisticated boronic acid derivative and a high-value building block in modern synthetic chemistry. Its core value lies in its dual functionality, combining a protected amino group with a boronic acid moiety, making it an essential intermediate for constructing complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, particularly for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology and CNS drug discovery programs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to create biaryl structures, a fundamental reaction in medicinal and process chemistry.
• Protease Inhibitor Development: Serves as a precursor in the design and synthesis of boronic acid-based protease inhibitors.
• Agrochemical Synthesis: Intermediate for creating novel herbicides and fungicides with enhanced activity and selectivity.
• Material Science Research: Used in the development of organic electronic materials and advanced polymers.
• Bioconjugation and Probe Synthesis: Facilitates the creation of fluorescent probes and bioconjugates for diagnostic and biochemical research.

Basic Information

Product Name	(3-{[(Benzyloxy)Carbonyl]Amino}-4,5-Difluorophenyl)Boronic Acid
CAS No.	2377609-82-8
Molecular Formula	C14H12BF2NO4
Molecular Weight	307.06 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-3-borono-4,5-difluoroaniline; 3-[(Carbobenzyloxy)amino]-4,5-difluorobenzeneboronic acid; (Z)-3-Amino-4,5-difluorophenylboronic acid; Cbz-3-Amino-4,5-difluorophenylboronic acid; 3-(N-Cbz-amino)-4,5-difluorophenylboronic acid; 4,5-Difluoro-3-[(phenylmethoxy)carbonyl]aminobenzeneboronic acid; B-[3-[[(Phenylmethoxy)carbonyl]amino]-4,5-difluorophenyl]boronic acid
EINECS	Contact for details

Quality Control

Our (3-{[(Benzyloxy)Carbonyl]Amino}-4,5-Difluorophenyl)Boronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive applications. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). Our quality commitment includes rigorous testing to meet the stringent requirements of pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and easily oxidized, requiring careful handling to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.