Description

2-Hydroxy-5-[(Trifluoromethyl)Sulfanyl]Phenylboronic Acid is a specialized organoboron compound featuring a unique trifluoromethylthio (-SCF₃) substituent, a functional group of high interest in modern synthetic chemistry. This compound matters as a versatile building block for the synthesis of complex molecules, particularly in the development of pharmaceuticals and agrochemicals where the introduction of fluorine-containing groups is crucial for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in Suzuki-Miyaura cross-coupling reactions and other catalytic transformations.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the -SCF₃ group can enhance membrane permeability and metabolic resistance.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the unique physicochemical properties of the trifluoromethylthio moiety.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, or organic electronic materials requiring specific fluorine-thioether motifs.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents to study enzyme function and biological pathways.
• Catalytic Ligand Precursor: Can be utilized to develop novel ligands for transition metal catalysis, enabling new reaction methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-Hydroxy-5-[(Trifluoromethyl)Sulfanyl]Phenylboronic Acid
CAS No.	2377609-27-1
Molecular Formula	C₇H₆BF₃O₂S
Molecular Weight	237.99 g/mol
Synonyms	(5-((Trifluoromethyl)thio)-2-hydroxyphenyl)boronic acid; 2-Hydroxy-5-(trifluoromethylsulfanyl)benzeneboronic acid; 5-(Trifluoromethylthio)-2-hydroxybenzeneboronic acid; 2-Hydroxy-5-(trifluoromethylthio)phenylboronic acid; Boronic acid, B-[5-[(trifluoromethyl)thio]-2-hydroxyphenyl]-; CAS 2377609-27-1
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-[(Trifluoromethyl)Sulfanyl]Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.