Description

5-(Benzyloxy)-2-Chloro-4-(Trifluoromethyl)Phenylboronic Acid is a high-purity, synthetically valuable boronic acid derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation, which is essential for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of advanced herbicides and fungicides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and liquid crystals with tailored electronic or optical properties.
• Chemical Biology: Employed as a probe or linker in bioconjugation and the development of chemical tools for proteomics and diagnostic assays.
• Catalyst Ligand Synthesis: Utilized to create novel bidentate or monodentate ligands for transition metal catalysts used in asymmetric synthesis.
• Academic & Contract Research: A fundamental reagent for methodological development in organic chemistry laboratories and for custom synthesis projects.

Basic Information

Item	Details
Product Name	5-(Benzyloxy)-2-Chloro-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	2377608-74-5
Molecular Formula	C14H11BClF3O3
Molecular Weight	330.50 g/mol
Synonyms	[2-Chloro-5-(phenylmethoxy)-4-(trifluoromethyl)phenyl]boronic acid; 2-Chloro-5-benzyloxy-4-trifluoromethylphenylboronic acid; 5-Benzyloxy-2-chloro-4-trifluoromethylbenzeneboronic acid; (5-(Benzyloxy)-2-chloro-4-(trifluoromethyl)phenyl)boronic acid; B-[2-Chloro-5-(phenylmethoxy)-4-(trifluoromethyl)phenyl]boronic acid; CAS 2377608-74-5
EINECS	Contact for details

Quality Control

Every batch of 5-(Benzyloxy)-2-Chloro-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.