Description

3-Bromo-5-Chloro-2-Fluorophenylboronic Acid is a high-purity, multi-halogenated boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its unique halogen substitution pattern, which enables precise cross-coupling reactions for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct complex, halogenated aromatic cores found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating functional organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals.
• Chemical Biology Probes: Employed in the development of molecular probes and bioconjugates for diagnostic and research applications.
• Catalyst Ligand Development: The boronic acid group can be utilized to create novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-Bromo-5-Chloro-2-Fluorophenylboronic Acid
CAS No.	2377608-61-0
Molecular Formula	C6H4BBrClFO2
Molecular Weight	253.26 g/mol
Synonyms	(3-Bromo-5-chloro-2-fluorophenyl)boronic acid; 2-Fluoro-3-bromo-5-chlorophenylboronic acid; B-(3-Bromo-5-chloro-2-fluorophenyl)boronic acid; 3-Bromo-5-chloro-2-fluorobenzeneboronic acid; Boronic acid, B-(3-bromo-5-chloro-2-fluorophenyl)-; 2377608-61-0; 3-Br-5-Cl-2-F-C6H2B(OH)2
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chloro-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.