Description

3-Bromo-5-Chloro-4-Fluorophenylboronic Acid is a high-purity, multi-halogenated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in enabling precise cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Employed in the development of organic electronic materials, including OLEDs and semiconductors, due to its halogenated aromatic structure.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Facilitates the creation of tagged molecules and bioconjugates for proteomics and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-Bromo-5-Chloro-4-Fluorophenylboronic Acid
CAS No.	2377608-50-7
Molecular Formula	C6H4BBrClFO2
Molecular Weight	253.26 g/mol
Synonyms	(3-Bromo-5-chloro-4-fluorophenyl)boronic acid; B-(3-Bromo-5-chloro-4-fluorophenyl)boronic acid; 3-Bromo-5-chloro-4-fluorobenzeneboronic acid; Boronic acid, B-(3-bromo-5-chloro-4-fluorophenyl)-; 2377608-50-7; 3-Br-5-Cl-4-F-PhB(OH)2
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Chloro-4-Fluorophenylboronic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure reliable performance in your sensitive synthetic processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and accompany each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.