Description

(2R,2'R,3R,3'R)-3,3'-Di-tert-Butyl-4,4'-Bis((R)-2-Methyl-1-Phenylpropoxy)-2,2',3,3'-Tetrahydro-2,2'-Bibenzo[D][1,3]Oxaphosphole CAS NO 2376521-83-2 is a sophisticated, chiral organophosphorus compound characterized by its binaphthol-derived backbone and sterically hindered substituents. This compound matters as a highly effective chiral ligand or catalyst precursor in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to control stereochemistry in critical bond-forming reactions.

Application

• Asymmetric Catalysis: Serving as a privileged chiral ligand for transition metal-catalyzed reactions such as hydrogenation, hydroformylation, and cross-coupling.
• Pharmaceutical Intermediate Synthesis: Enabling the stereoselective construction of complex active pharmaceutical ingredients (APIs) and key chiral building blocks.
• Agrochemical Production: Facilitating the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: Acting as a chiral dopant or building block for advanced polymeric materials and liquid crystals.
• Methodology Development: Used in academic and industrial research laboratories to develop new asymmetric synthetic protocols.
• Fine Chemical Manufacturing: Critical for producing high-value, optically pure flavors, fragrances, and specialty chemicals.

Basic Information

Product Name	(2R,2'R,3R,3'R)-3,3'-Di-tert-Butyl-4,4'-Bis((R)-2-Methyl-1-Phenylpropoxy)-2,2',3,3'-Tetrahydro-2,2'-Bibenzo[D][1,3]Oxaphosphole
CAS No.	2376521-83-2
Molecular Formula	C48H58O4P2
Molecular Weight	776.90 g/mol
Synonyms	(R,R)-3,3'-Di-tert-butyl-4,4'-bis[(R)-2-methyl-1-phenylpropoxy]-2,2',3,3'-tetrahydro-2,2'-bibenzo[d][1,3]oxaphosphole; (R,R)-DTB-BIBOP; DTB-BIBOP Ligand; (R,R)-DTB-BIBOP; Chiral Binaphthol-Based Phosphite Ligand; P-OP Chiral Ligand; (2R,2'R,3R,3'R)-DTB-BIBOP; Asymmetric Phosphite Ligand
EINECS	Contact for details

Quality Control

Our production of this advanced chiral chemical adheres to strict quality management protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to ensure high enantiomeric excess (ee) and chemical purity, critical for reproducible catalytic performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is sensitive to oxidation and prolonged exposure to air or light may affect its performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.