Description

2-(3',5'-Difluoro-[1,1'-Biphenyl]-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 2250042-17-0 is a high-purity, advanced pharmaceutical intermediate belonging to the class of organoboron compounds. This compound is a critical building block in modern synthetic chemistry, enabling the efficient construction of complex molecules through cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biphenyl-based active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides containing difluorobiphenyl motifs.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for bioimaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(3',5'-Difluoro-[1,1'-Biphenyl]-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2250042-17-0
Molecular Formula	C24H25BF2O2
Molecular Weight	394.27 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[3,5-difluoro-4'-biphenylyl]-1,3,2-dioxaborolane; 2-(3',5'-Difluorobiphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3,5-Difluoro-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl; Biphenyl-2-ylboronic acid pinacol ester derivative; (3',5'-Difluoro[1,1'-biphenyl]-4-yl)boronic acid pinacol ester; CAS 2250042-17-0
EINECS	Contact for details

Quality Control

Our 2-(3',5'-Difluoro-[1,1'-Biphenyl]-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.