Description

Cyclopropanecarboxylic Acid, 1-[4-(1,1-Dimethylethyl)Phenyl]-2,2-Difluoro- is a high-value, fluorinated cyclopropane derivative characterized by its unique structural motif combining a tert-butylphenyl group with a difluorocyclopropane carboxylic acid. This compound matters as a sophisticated chemical intermediate and key building block in advanced organic synthesis, enabling the introduction of steric bulk and fluorine atoms to modulate the properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and production of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and oncology, where the difluorocyclopropane moiety can enhance metabolic stability and bioavailability.
• Agrochemical Active Ingredient Synthesis: Used as a building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms and rigid cyclopropane structure for improved efficacy and environmental profile.
• Advanced Material Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials, where its specific geometry and fluorine content can fine-tune material properties like thermal stability, dielectric constant, and optical activity.
• Medicinal Chemistry & SAR Studies: Provides a versatile scaffold for structure-activity relationship (SAR) exploration, allowing researchers to investigate the impact of the tert-butylphenyl and difluorocyclopropane groups on biological activity and selectivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) and research institutions for custom synthesis projects requiring this specific, high-purity fluorinated intermediate.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-[4-(1,1-Dimethylethyl)Phenyl]-2,2-Difluoro-
CAS No.	2228360-01-6
Molecular Formula	C14H16F2O2
Molecular Weight	254.28 g/mol
Synonyms	1-(4-tert-Butylphenyl)-2,2-difluorocyclopropanecarboxylic Acid; 2,2-Difluoro-1-[4-(tert-butyl)phenyl]cyclopropanecarboxylic Acid; 1-[4-(tert-Butyl)phenyl]-2,2-difluorocyclopropanecarboxylic Acid; 4-(1,1-Dimethylethyl)-α-(difluoromethylene)benzenecacetic acid, γ-lactone (related); Difluorocyclopropane Carboxylic Acid Derivative; tert-Butylphenyl Difluorocyclopropanecarboxylate
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 1-[4-(1,1-Dimethylethyl)Phenyl]-2,2-Difluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material is suitable for demanding R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.