Description

2-(2-Fluoro-4-(Trifluoromethyl)Phenyl)Cyclopropane-1-Carboxylic Acid is a high-value, fluorinated cyclopropane carboxylic acid derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both fluorine and a trifluoromethyl group on the aromatic ring, makes it an essential building block for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used as a precursor for developing next-generation herbicides, fungicides, and insecticides, where the fluorinated cyclopropane moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a sophisticated building block for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials where fluorinated aromatic systems are required for specific performance characteristics.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	2-(2-Fluoro-4-(Trifluoromethyl)Phenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	2227851-53-6
Molecular Formula	C11H8F4O2
Molecular Weight	248.17 g/mol
Synonyms	2-(2-Fluoro-4-(trifluoromethyl)phenyl)cyclopropanecarboxylic acid; 2-(2-Fluoro-α,α,α-trifluoro-p-tolyl)cyclopropanecarboxylic acid; [2-(2-Fluoro-4-trifluoromethylphenyl)cyclopropyl]carboxylic acid; Cyclopropanecarboxylic acid, 2-[2-fluoro-4-(trifluoromethyl)phenyl]-; 2-Fluoro-4-(trifluoromethyl)phenylcyclopropanecarboxylic acid; CAS 2227851-53-6
EINECS	Contact for details

Quality Control

Our production of 2-(2-Fluoro-4-(Trifluoromethyl)Phenyl)Cyclopropane-1-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.