Description

({[(2R,3S,4R,5R)-5-[2-Chloro-6-(cyclopentylamino)-9H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy}methyl)phosphonic acid is a high-purity, advanced pharmaceutical intermediate featuring a complex nucleoside analog structure. This compound matters for its critical role in the research and development of novel antiviral and anticancer therapeutics, where precise molecular architecture is paramount for biological activity. It is primarily needed by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of next-generation nucleotide-based drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analog prodrugs targeting viral polymerases.
• Antiviral Drug Research: Precursor for the development of potential therapeutics against hepatitis B virus (HBV), hepatitis C virus (HCV), and other viral infections.
• Oncology Research: Used in the discovery of nucleotide-based anticancer agents that interfere with DNA/RNA synthesis in rapidly dividing cells.
• Biochemical Tool Compound: Serves as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleotide metabolism.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for clinical trial material (CTM) production.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of drug candidates.

Basic Information

Product Name	({[(2R,3S,4R,5R)-5-[2-Chloro-6-(cyclopentylamino)-9H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy}methyl)phosphonic Acid
CAS No.	2216763-68-5
Molecular Formula	C16H23ClN5O7P
Molecular Weight	463.81 g/mol
Synonyms	2-Chloro-N-cyclopentyl-9-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[[(phosphonomethoxy)methyl]oxolan-2-yl]purin-6-amine; (2R,3S,4R,5R)-2-[2-Chloro-6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol 1-[(phosphonomethoxy)methyl] ether; Cyclopentylamino Chloropurine Phosphonate Nucleoside; 2'-Phosphonomethoxyethyl Derivative of 2-Chloro-N-cyclopentyladenosine (Analog); PME Derivative of 2-Cl-cPent-Ado; Contact for additional aliases.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR (1H, 13C, 31P), and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development needs from milligram to kilogram scale with a commitment to cGMP-compliant practices where required.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.