Description

(2R,2'S,3R,3'R)-3,3'-Di-tert-Butyl-2,2'-Diisopropyl-2,2',3,3'-Tetrahydro-4,4'-Bibenzo[D][1,3]Oxaphosphole CAS NO 2214207-75-5 is a high-purity, chiral organophosphorus compound characterized by its unique binaphthol-derived oxaphosphole structure. This compound is of significant commercial interest as a highly effective chiral ligand or catalyst precursor in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily required by R&D laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to optimize stereoselective transformations.

Application

• Asymmetric Catalysis: Serving as a privileged chiral ligand for transition metal-catalyzed reactions such as hydrogenation, hydroformylation, and cross-coupling.
• Pharmaceutical Intermediate Synthesis: Enabling the stereocontrolled construction of complex active pharmaceutical ingredients (APIs) for novel therapeutics.
• Agrochemical Production: Facilitating the synthesis of enantiomerically pure herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Material Science Research: Acting as a building block or chiral dopant for the development of advanced polymeric materials and liquid crystals.
• Academic & Industrial R&D: Used in method development and discovery chemistry for exploring new asymmetric synthetic pathways.
• Process Chemistry Optimization: Scaling up and optimizing catalytic processes for cost-effective manufacturing of chiral molecules.

Basic Information

Product Name	(2R,2'S,3R,3'R)-3,3'-Di-tert-Butyl-2,2'-Diisopropyl-2,2',3,3'-Tetrahydro-4,4'-Bibenzo[D][1,3]Oxaphosphole
CAS No.	2214207-75-5
Molecular Formula	C34H44O2P2
Molecular Weight	546.64 g/mol
Synonyms	(R,R,S,S)-DTB-DIOPH; 3,3'-Di-tert-butyl-2,2'-diisopropyl-2,2',3,3'-tetrahydro-4,4'-bibenzo[d][1,3]oxaphosphole; Chiral Binaphthol Oxaphosphole Ligand; DTB-DIOPH Ligand; (2R,2'S,3R,3'R)-DTB-DIOPH; Asymmetric Phosphole Ligand; P-Chiral Ligand; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including Chiral HPLC, NMR (¹H, ³¹P, ¹³C), and mass spectrometry to confirm enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral assay, and impurity profile is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and efficacy. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.