Description

4-[(3-Aminopropyl)Amino]-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hcl is a high-purity, small molecule compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel therapeutic agents, particularly in targeted protein degradation and immunomodulatory drug discovery. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology, immunology, and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of Proteolysis Targeting Chimeras (PROTACs) and other bifunctional molecules.
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Probe Development: Serves as a core component in the design of molecular probes for studying ubiquitin-proteasome system (UPS) pathways.
• Preclinical Development: Employed in the synthesis of candidate compounds for pharmacokinetic and pharmacodynamic evaluation.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology and targeted protein degradation.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis and scale-up projects under cGMP or non-GMP conditions.

Basic Information

Product Name	4-[(3-Aminopropyl)Amino]-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hydrochloride
CAS No.	2154342-45-5
Molecular Formula	C17H20ClN5O4
Molecular Weight	393.82 g/mol
Synonyms	4-[(3-Aminopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride; Lenalidomide-PEG3-amine hydrochloride; (S)-3-(4-((3-aminopropyl)amino)-1,3-dioxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride; E3 Ligase Ligand-Linker Conjugate 17 hydrochloride; Cereblon Ligand-Linker Conjugate 4 hydrochloride; PROTAC Linker 17 hydrochloride; Thalidomide-PEG3-amine hydrochloride (common name); (S)-2-(2,6-Dioxopiperidin-3-yl)-4-((3-aminopropyl)amino)isoindoline-1,3-dione hydrochloride
EINECS	Contact for details

Quality Control

Our 4-[(3-Aminopropyl)Amino]-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR, MS, and IR. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Material can be supplied in research-grade or under cGMP conditions for advanced preclinical and clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry and well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.