Description

2-Fluoro-3-Hydroxyphenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its stability as a protected boronic ester, which facilitates handling and storage compared to its free acid form. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecules via cross-coupling reactions.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, essential for creating biaryl structures in drug discovery.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) and candidate molecules, particularly those requiring a fluorinated phenolic scaffold.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the specific fluorinated aromatic moiety imparts desired biological activity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and functional materials.
• Materials Science Research: Acts as a monomer or precursor in the development of advanced polymers, OLED materials, and other functional organic materials.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Product Name	2-Fluoro-3-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	2121514-67-6
Molecular Formula	C₁₂H₁₆BFO₃
Molecular Weight	238.07 g/mol
Synonyms	(2-Fluoro-3-hydroxyphenyl)boronic acid pinacol ester; 2-Fluoro-3-hydroxybenzeneboronic acid pinacol ester; Pinacol (2-fluoro-3-hydroxyphenyl)boronate; (3-Hydroxy-2-fluorophenyl)boronic acid pinacol ester; B-(2-Fluoro-3-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(2-fluoro-3-hydroxyphenyl)-1,3,2-dioxaborolane; CAS 2121514-67-6
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.