Description

2-Methoxy-4-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound matters because it provides a protected, air-stable form of the corresponding boronic acid, enabling efficient and reliable Suzuki-Miyaura cross-coupling reactions under demanding conditions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecules containing the valuable 2-methoxy-4-(trifluoromethoxy)phenyl moiety.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, where its aromatic and fluorinated structure contributes to desired electronic and morphological properties.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and functionalized materials requiring precise aromatic coupling.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and bioconjugates for diagnostic and research applications.
• Cross-Coupling Reactions: The primary application is in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl structures efficiently.

Basic Information

Product Name	2-Methoxy-4-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester
CAS No.	2121514-61-0
Molecular Formula	C14H18BF3O4
Molecular Weight	318.10 g/mol
Synonyms	2-Methoxy-4-(trifluoromethoxy)benzeneboronic acid pinacol ester; 4-(Trifluoromethoxy)-2-methoxyphenylboronic acid pinacol ester; (2-Methoxy-4-(trifluoromethoxy)phenyl)boronic acid pinacol ester; Pinacol [2-methoxy-4-(trifluoromethoxy)phenyl]boronate; 2-Methoxy-4-trifluoromethoxyphenylboronic acid pinacol ester; B-[2-Methoxy-4-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain optimal purity. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.