Description

4-Bromo-3-Chloro-2-Fluorophenylboronic Acid is a high-purity, multi-halogenated boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex halogenated aromatic scaffolds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the specific halogen pattern can influence biological activity and environmental stability.
• Suzuki-Miyaura Cross-Coupling: Acts as a versatile boronic acid coupling partner for forming carbon-carbon bonds with aryl or vinyl halides, a cornerstone reaction in medicinal and process chemistry.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands and organometallic catalysts for asymmetric synthesis and other advanced catalytic processes.
• Material Science Research: Used in the synthesis of organic electronic materials, such as those for OLEDs or organic photovoltaics, where halogenated units tune electronic properties.
• Chemical Biology Probes: Serves as a building block for creating molecular probes and tags used in biochemical and cellular research.

Basic Information

Product Name	4-Bromo-3-Chloro-2-Fluorophenylboronic Acid
CAS No.	2121514-49-4
Molecular Formula	C6H4BBrClFO2
Molecular Weight	253.26 g/mol
Synonyms	(4-Bromo-3-chloro-2-fluorophenyl)boronic acid; 2-Fluoro-4-bromo-3-chlorophenylboronic acid; 4-Bromo-3-chloro-2-fluorobenzeneboronic acid; B-(4-Bromo-3-chloro-2-fluorophenyl)boronic acid; Boronic acid, B-(4-bromo-3-chloro-2-fluorophenyl)-; 2121514-49-4; 4-Br-3-Cl-2-F-C6H2B(OH)2
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Chloro-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening a new container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.