Description

5-Fluoro-3-Piperidinophenylboronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound matters because its protected boronic ester functionality offers superior stability and handling characteristics compared to the free acid, facilitating complex cross-coupling reactions. It is primarily needed by pharmaceutical and agrochemical R&D teams for constructing novel molecules, particularly in the development of active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and the boronic ester group.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Serves as a building block for creating new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Employed in the synthesis of advanced organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals.
• Chemical Biology & Proteomics: Utilized as a molecular probe or tag in bioconjugation and target identification studies.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening.

Basic Information

Product Name	5-Fluoro-3-Piperidinophenylboronic Acid Pinacol Ester
CAS No.	2121514-28-9
Molecular Formula	C₁₇H₂₅BFNO₂
Molecular Weight	305.20 g/mol
Synonyms	3-(Piperidin-1-yl)-5-fluorophenylboronic acid pinacol ester; 5-Fluoro-3-(1-piperidinyl)benzeneboronic acid pinacol ester; (5-Fluoro-3-piperidin-1-ylphenyl)boronic acid pinacol ester; 1-Piperidine, 1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluorophenyl)-; 5-Fluoro-3-piperidin-1-ylbenzeneboronic acid pinacol ester; 2121514-28-9; B-(5-Fluoro-3-(1-piperidinyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-Piperidinophenylboronic Acid Pinacol Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.