Description

2-(Hydroxymethyl)-5-(Trifluoromethoxy)Phenylboronic Acid is a specialized organoboron building block featuring both hydroxymethyl and trifluoromethoxy functional groups. This compound is critical for the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research, where its unique structure enables the introduction of key pharmacophores. It is primarily utilized by R&D chemists and process development scientists in the life sciences and advanced materials sectors for Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the trifluoromethoxy group for enhanced biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: An essential boronic acid reagent for forming carbon-carbon bonds in complex molecule assembly, prized for its stability and reactivity.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-(Hydroxymethyl)-5-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	2121514-23-4
Molecular Formula	C8H8BF3O4
Molecular Weight	235.96 g/mol
Synonyms	[5-(Trifluoromethoxy)-2-(hydroxymethyl)phenyl]boronic acid; 2-(Hydroxymethyl)-5-(trifluoromethoxy)benzeneboronic acid; (5-Trifluoromethoxy-2-hydroxymethylphenyl)boronic acid; 2-Hydroxymethyl-5-trifluoromethoxyphenylboronic acid; Boronic acid, B-[5-(trifluoromethoxy)-2-(hydroxymethyl)phenyl]-; CAS 2121514-23-4
EINECS	Contact for details

Quality Control

Our 2-(Hydroxymethyl)-5-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.