Description

4-Benzyloxy-2,6-Difluorophenylboronic Acid Pinacol Ester is a high-purity, organoboron building block crucial for modern synthetic chemistry. This compound matters as a protected boronic acid derivative, offering enhanced stability and handling characteristics for complex cross-coupling reactions. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for constructing advanced molecular scaffolds in drug discovery and material science applications.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl and benzyloxy motifs.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific activity profiles.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organometallic chemistry.
• Material Science Research: A precursor for organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	4-Benzyloxy-2,6-Difluorophenylboronic Acid Pinacol Ester
CAS No.	2121514-21-2
Molecular Formula	C19H21BF2O3
Molecular Weight	346.18 g/mol
Synonyms	4-(Benzyloxy)-2,6-difluorophenylboronic acid pinacol ester; 2,6-Difluoro-4-(phenylmethoxy)benzeneboronic acid pinacol ester; 4-(Benzyloxy)-2,6-difluorobenzeneboronic acid pinacol ester; B-[4-(Benzyloxy)-2,6-difluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-(Benzyloxy)-2,6-difluorophenyl)boronic acid pinacol ester; Pinacol 4-(benzyloxy)-2,6-difluorophenylboronate; CAS 2121514-21-2
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-2,6-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting traceability and compliance for research and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.