Description

2-Bromo-6-Fluoro-3-Methylphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for constructing complex biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex fluorinated and brominated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where specific halogenated aromatic motifs are required for bioactivity.
• Material Science Research: Employed in the creation of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular architecture is essential.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein functions.
• Custom Synthesis and Contract Manufacturing: A vital reagent for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) serving the global pharmaceutical and biotechnology industries.

Basic Information

Item	Details
Product Name	2-Bromo-6-Fluoro-3-Methylphenylboronic Acid Pinacol Ester
CAS No.	2121512-72-7
Molecular Formula	C₁₃H₁₇BBrFO₂
Molecular Weight	313.99 g/mol
Synonyms	2-Bromo-6-fluoro-3-methylbenzeneboronic acid pinacol ester; (2-Bromo-6-fluoro-3-methylphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2-bromo-6-fluoro-3-methylphenyl)-1,3,2-dioxaborolane; 2-(2-Bromo-6-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-(2-bromo-6-fluoro-3-methylphenyl)-, 1,1-dimethylethyl ester; Pinacol (2-bromo-6-fluoro-3-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Fluoro-3-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with full characterization data are provided to guarantee consistency and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.