Description

5-(3,4-Difluorophenyl)-3-Methyl-1H-Pyrrole-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrole-carboxylic acid scaffold substituted with a difluorophenyl group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with potential for enhanced metabolic stability and target selectivity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel small-molecule drugs.
• API Synthesis: Used in the construction of complex molecular architectures for potential Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Can be utilized to develop tool compounds for investigating biological pathways and target validation.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for bespoke chemical synthesis projects.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and novel heterocycle development.

Basic Information

Product Name	5-(3,4-Difluorophenyl)-3-Methyl-1H-Pyrrole-2-Carboxylic Acid
CAS No.	2111067-88-8
Molecular Formula	C12H9F2NO2
Molecular Weight	237.20 g/mol
Synonyms	3-Methyl-5-(3,4-difluorophenyl)-1H-pyrrole-2-carboxylic acid; 1H-Pyrrole-2-carboxylic acid, 5-(3,4-difluorophenyl)-3-methyl-; 5-(3,4-Difluorophenyl)-3-methyl-1H-pyrrole-2-carboxylic acid; 2111067-88-8; Difluorophenyl methylpyrrole carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(3,4-Difluorophenyl)-3-Methyl-1H-Pyrrole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with the standards expected for pharmaceutical R&D, including compliance with relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere for long-term storage to ensure maximum stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.