Description

Belumosudil/Kd-025 CAS NO 2109704-99-4 is a potent and selective Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor. This small molecule is critical for targeted therapeutic development, offering a mechanism to modulate immune responses and fibrotic pathways. It is primarily required by pharmaceutical R&D organizations, contract research organizations (CROs), and academic institutions engaged in the discovery and development of treatments for chronic graft-versus-host disease (cGVHD), fibrotic diseases, and autoimmune conditions.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control in drug substance and product manufacturing.
• Preclinical Research: Used in in vitro and in vivo studies to investigate the pharmacological effects of ROCK2 inhibition.
• Drug Discovery & Development: A key intermediate or active pharmaceutical ingredient (API) in the synthesis and formulation of novel therapeutic candidates targeting ROCK2 pathways.
• Mechanistic Studies: Employed in biochemical and cellular assays to elucidate the role of ROCK2 in various disease models, including fibrosis and immunology.
• Clinical Trial Material (CTM) Manufacturing: Used in the production of batches for clinical studies under appropriate quality guidelines.

Basic Information

Product Name	Belumosudil/Kd-025
CAS No.	2109704-99-4
Molecular Formula	C₂₇H₃₂N₆O₃
Molecular Weight	488.58 g/mol
Synonyms	Belumosudil; KD025; SLx-2119; Rezurock; 2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide; ROCK2 Inhibitor KD-025; SLx 2119
EINECS	Contact for details

Quality Control

Our Belumosudil/Kd-025 is manufactured and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, MS, NMR), and residual solvent analysis to ensure it meets high-purity standards suitable for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.