Description

5-Chloro-3-Fluoro-4-Isopropoxyphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules via cross-coupling reactions, enabling the development of advanced materials and pharmaceuticals. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for Suzuki-Miyaura and other palladium-catalyzed couplings.

Application

This versatile boronic acid pinacol ester is primarily employed as a sophisticated coupling partner in organic synthesis. Its specific applications include:

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the chloro-fluoro-isopropoxy substitution pattern imparts specific biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of advanced organic electronic materials, such as polymers for OLEDs or organic photovoltaics.
• Ligand and Catalyst Development: Utilized to construct complex ligand frameworks for transition metal catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Incorporated into molecular probes and tags for studying biological processes and protein interactions.
• Scalable Process Chemistry: Suitable for use in pilot plant and commercial-scale manufacturing due to its stability and predictable reactivity profile.

Basic Information

Item	Details
Product Name	5-Chloro-3-Fluoro-4-Isopropoxyphenylboronic Acid
CAS No.	2096335-18-9
Molecular Formula	C9H11BClFO3
Molecular Weight	231.45 g/mol
Synonyms	(5-Chloro-3-fluoro-4-isopropoxyphenyl)boronic acid; 5-Chloro-3-fluoro-4-(1-methylethoxy)benzeneboronic acid; 4-Isopropoxy-5-chloro-3-fluorophenylboronic acid; Boronic acid, B-(5-chloro-3-fluoro-4-isopropoxyphenyl)-; CAS 2096335-18-9
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Fluoro-4-Isopropoxyphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C for prolonged periods; allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.