Description

2-Butoxy-4-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound featuring a trifluoromethyl and a butoxy substituent on the aromatic ring. This structure makes it a valuable building block in modern synthetic chemistry, particularly for Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by R&D and production chemists in the pharmaceutical and agrochemical industries to introduce complex aryl fragments into target molecules, enabling the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group is a critical pharmacophore.
• Material Science Research: Serves as a precursor for synthesizing novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Chemical Biology & Diagnostics: Employed in the synthesis of molecular probes and biomarkers for imaging and diagnostic applications.
• Catalyst & Ligand Development: Acts as a starting material for creating novel boron-containing catalysts and ligands for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-specific projects requiring this precise boronic acid derivative.

Basic Information

Product Name	2-Butoxy-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	2096335-15-6
Molecular Formula	C11H14BF3O3
Molecular Weight	262.04 g/mol
Synonyms	[2-Butoxy-4-(trifluoromethyl)phenyl]boronic acid; 2-Butoxy-α,α,α-trifluoro-p-tolylboronic acid; 4-Butoxy-3-(trifluoromethyl)benzeneboronic acid; 2-Butoxy-4-trifluoromethylbenzeneboronic Acid; B-[2-Butoxy-4-(trifluoromethyl)phenyl]boronic acid; (2-Butoxy-4-(trifluoromethyl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Butoxy-4-(Trifluoromethyl)Phenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.