Description

5-(T-Butyldimethylsilyloxy)-2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern organic synthesis, enabling the formation of complex carbon-carbon bonds via cross-coupling reactions. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl and heterobiaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require fluorinated and trifluoromethylated aromatic motifs for enhanced bioactivity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of advanced organic electronic materials, such as OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis and organocatalysis.
• Chemical Biology Probes: Useful for the synthesis of tagged molecules and probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	5-(T-Butyldimethylsilyloxy)-2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid
CAS No.	2096335-06-5
Molecular Formula	C₁₃H₁₉BF₄O₂Si
Molecular Weight	326.19 g/mol
Synonyms	[5-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-fluoro-3-(trifluoromethyl)benzeneboronic Acid; 2-Fluoro-3-(trifluoromethyl)-5-[(tert-butyldimethylsilyl)oxy]phenylboronic Acid; 5-(tert-Butyldimethylsilyloxy)-2-fluoro-3-(trifluoromethyl)benzeneboronic Acid; 5-(TBDMSO)-2-Fluoro-3-(CF3)Phenylboronic Acid; Boronic Acid, B-[5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-fluoro-3-(trifluoromethyl)phenyl]-; 2096335-06-5
EINECS	Contact for details

Quality Control

Our production of 5-(T-Butyldimethylsilyloxy)-2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be kept tightly sealed and handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.