Description

3-Nitro-4-(Trifluoromethoxy)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in its role as a key building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in modern pesticides and herbicides, contributing to improved efficacy and selectivity.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and organic photovoltaics, due to its electron-withdrawing nitro and trifluoromethoxy groups.
• Chemical Biology Probes: Utilized to develop boronic acid-based sensors and probes for detecting biological analytes like sugars or peroxides.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	3-Nitro-4-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	2096333-99-0
Molecular Formula	C7H5BF3NO5
Molecular Weight	250.93 g/mol
Synonyms	[3-Nitro-4-(trifluoromethoxy)phenyl]boronic acid; (3-Nitro-4-(trifluoromethoxy)phenyl)boronic acid; 3-Nitro-4-trifluoromethoxybenzeneboronic acid; 4-Trifluoromethoxy-3-nitrobenzeneboronic acid; Boronic acid, B-[3-nitro-4-(trifluoromethoxy)phenyl]-; 3-Nitro-4-(trifluoromethoxy)benzeneboronic acid; 2-Nitro-4-boronobenzotrifluoromethyl ether
EINECS	Contact for details

Quality Control

Every batch of 3-Nitro-4-(Trifluoromethoxy)Phenylboronic Acid undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for advanced synthetic applications. Our quality commitment includes compliance with relevant internal specifications and industry best practices. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.