Description

2-Hydroxy-6-Trifluoromethylphenylboronic Acid is a specialized organoboron compound featuring both a boronic acid and a phenolic hydroxyl group on a trifluoromethyl-substituted aromatic ring. This unique bifunctional structure makes it a highly valuable building block in modern synthetic chemistry, particularly for the construction of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular architecture. The compound's properties enable the efficient synthesis of fluorinated biaryl structures, which are critical motifs in active ingredient development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl and biaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorine atoms and boronic acid group allow for targeted molecular design.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units are desirable.
• Chemical Biology & Probe Synthesis: Utilized for creating molecular probes and inhibitors that target specific enzymes or biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	2-Hydroxy-6-Trifluoromethylphenylboronic Acid
CAS No.	2096333-79-6
Molecular Formula	C7H6BF3O3
Molecular Weight	205.93 g/mol
Synonyms	(2-Hydroxy-6-(trifluoromethyl)phenyl)boronic acid; 2-Borono-6-(trifluoromethyl)phenol; 6-Trifluoromethyl-2-hydroxybenzeneboronic acid; 2-Hydroxy-6-trifluoromethylbenzeneboronic acid; 2-(Trifluoromethyl)-6-hydroxybenzeneboronic acid; Boronic acid, B-[2-hydroxy-6-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-6-Trifluoromethylphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and cGMP-grade synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.