Description

Cyclopropanamine, 2,2-Difluoro-, Hydrochloride (1:1), (1R)- is a high-purity, single-enantiomer chiral building block of significant interest in advanced pharmaceutical research and development. This compound, with CAS number 2089150-96-7, is valued for its unique cyclopropane scaffold and fluorine substitution, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of novel drug candidates. It is primarily sought by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of targeted, high-value molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the metabolically stable, conformationally restricted cyclopropane motif.
• Agrochemical Synthesis: Serves as a building block for developing new generation pesticides and herbicides, where the difluorocyclopropane unit can enhance biological efficacy.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of enantiomerically pure compounds.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Incorporated into linker structures or warheads for the design of novel bifunctional molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	Cyclopropanamine, 2,2-Difluoro-, Hydrochloride (1:1), (1R)-
CAS No.	2089150-96-7
Molecular Formula	C3H6ClF2N
Molecular Weight	129.54 g/mol
Synonyms	(1R)-2,2-Difluorocyclopropanamine Hydrochloride; (R)-2,2-Difluorocyclopropan-1-amine Hydrochloride; (1R)-2,2-Difluorocyclopropylamine HCl; (R)-2,2-Difluorocyclopropylamine Hydrochloride; (R)-α,α-Difluorocyclopropanemethylamine HCl; (R)-1-Amino-2,2-difluorocyclopropane Hydrochloride; (R)-2,2-Difluoro-1-aminocyclopropane Hydrochloride
EINECS	Contact for details

Quality Control

Our (1R)-2,2-Difluorocyclopropanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, assay, enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.