Description

Isopropyl ((R)-((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)(Phenoxy)Phosphoryl)-D-Alaninate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel antiviral and anticancer therapeutics. This compound matters because it serves as a critical building block for prodrug development, enabling targeted drug delivery and enhanced bioavailability of active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of nucleotide analogs and other sophisticated small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleotide prodrugs for antiviral therapies targeting hepatitis B (HBV) and hepatitis C (HCV).
• Anticancer Drug Development: Used in research and manufacturing of nucleoside analogs designed to inhibit cancer cell proliferation.
• Prodrug Synthesis: Enables the creation of masked, bio-activatable forms of active compounds to improve pharmacokinetic profiles.
• Biochemical Research: Serves as a tool compound for studying enzyme kinetics and metabolic pathways involving nucleotide processing.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale production of specialty active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Isopropyl ((R)-((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)(Phenoxy)Phosphoryl)-D-Alaninate
CAS No.	2053424-88-5
Molecular Formula	C21H29N6O6P
Molecular Weight	492.47 g/mol
Synonyms	Isopropyl D-Alaninate Phosphoramidate of 6-Aminopurine; (R)-Isopropyl 2-(((((R)-1-(6-Aminopurin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphorylamino)propanoate; GS-7340 Intermediate; Tenofovir Alafenamide (TAF) Related Compound; Isopropyl ((R)-((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate; Phosphoramidate Prodrug Intermediate; 2053424-88-5; BMS-986001 Analog Intermediate
EINECS	Contact for details

Quality Control

Our Isopropyl ((R)-((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)(Phenoxy)Phosphoryl)-D-Alaninate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.