Description

2-[(2,6-Difluorophenyl)Methyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester, critical for modern synthetic chemistry. Its primary value lies in enabling the Suzuki-Miyaura cross-coupling reaction, a cornerstone method for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides.
• Material Science: Enables the creation of organic electronic materials, such as OLEDs and semiconductors, through controlled polymerization.
• Medicinal Chemistry: Facilitates the rapid exploration of chemical space in drug discovery programs via parallel synthesis and library generation.
• Chemical Research: Serves as a versatile reagent in academic and industrial R&D for developing new synthetic methodologies.
• Ligand & Catalyst Development: Used to prepare sophisticated boron-containing ligands for catalysis.

Basic Information

Product Name	2-[(2,6-Difluorophenyl)Methyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2052955-28-7
Molecular Formula	C₁₄H₁₉BF₂O₂
Molecular Weight	268.11 g/mol
Synonyms	(2,6-Difluorobenzyl)boronic acid pinacol ester; 2,6-Difluorobenzylboronic acid pinacol ester; 1-(2,6-Difluorophenyl)-N,N,N-trimethylmethanaminium boronate; 2-(2,6-Difluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2,6-difluorobenzyl)boronate; (2,6-Difluorobenzyl)BPin; 2,6-Difluorobenzyl MIDA Boronate (precursor related compound); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-[(2,6-Difluorophenyl)Methyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and GC/MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.