Description

4-(N,N-Dimethylaminomethyl)-3-Fluorophenylboronic Acid, Pinacol Ester is a sophisticated, multifunctional organoboron building block crucial for modern synthetic chemistry. Its value lies in the synergistic combination of a protected boronic acid group for cross-coupling reactions and a dimethylaminomethyl moiety that can serve as a directing group or be further functionalized. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in medicinal chemistry for creating novel drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key electrophile for constructing biaryl and heterobiaryl systems central to many active pharmaceutical ingredients (APIs).
• Medicinal Chemistry & Drug Discovery: Serving as a versatile intermediate for the synthesis of fluorinated drug-like molecules, leveraging the fluorine atom for metabolic stability and bioavailability.
• Agrochemical Intermediate: Used in the research and development of advanced, fluorinated pesticides and herbicides.
• Material Science Research: A precursor for synthesizing organic electronic materials and fluorinated liquid crystals.
• Chemical Biology Probes: Facilitating the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Process Chemistry Development: Enabling scalable routes to complex targets in pilot plant and manufacturing settings.

Basic Information

Product Name	4-(N,N-Dimethylaminomethyl)-3-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	2040476-05-7
Molecular Formula	C15H23BFNO2
Molecular Weight	279.16 g/mol
Synonyms	4-(Dimethylaminomethyl)-3-fluorobenzeneboronic acid pinacol ester; 3-Fluoro-4-((dimethylamino)methyl)phenylboronic acid pinacol ester; (3-Fluoro-4-((dimethylamino)methyl)phenyl)boronic acid pinacol ester; B-[3-Fluoro-4-[(dimethylamino)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[3-fluoro-4-(dimethylaminomethyl)phenyl]-1,3,2-dioxaborolane; 3-Fluoro-4-(N,N-dimethylaminomethyl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4-(N,N-Dimethylaminomethyl)-3-Fluorophenylboronic Acid, Pinacol Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.