Description

3-Cyano-4-(Trifluoromethyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular structure, featuring both a cyano and a trifluoromethyl group, makes it an essential reagent for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring the 3-cyano-4-(trifluoromethyl)phenyl moiety to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Employed in the creation of novel organic electronic materials, such as OLEDs and semiconductors, where its electronic properties are leveraged.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for palladium-catalyzed carbon-carbon bond formation, enabling the construction of biaryl structures common in many functional compounds.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Acts as a building block for creating molecular probes and inhibitors used in biochemical and cellular assays.

Basic Information

Product Name	3-Cyano-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	2016766-76-8
Molecular Formula	C9H5BF3NO2
Molecular Weight	227.95 g/mol
Synonyms	[3-Cyano-4-(trifluoromethyl)phenyl]boronic acid; 4-Trifluoromethyl-3-cyanophenylboronic acid; 3-Cyano-4-(trifluoromethyl)benzeneboronic acid; Boronic acid, B-[3-cyano-4-(trifluoromethyl)phenyl]-; (3-Cyano-4-trifluoromethylphenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 3-Cyano-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.