Description

Methyl 5-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzoate is a high-purity, multi-functionalized aromatic ester building block critical for advanced organic synthesis. Its unique halogen and trifluoromethyl substitution pattern makes it an exceptionally valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the halogen atoms for effective binding to biological targets.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional handles for further modification.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or labeling agent in the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs serving the life sciences sector.

Basic Information

Product Name	Methyl 5-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzoate
CAS No.	2007915-72-0
Molecular Formula	C10H5BrF4O2
Molecular Weight	313.05 g/mol
Synonyms	5-Bromo-2-fluoro-4-(trifluoromethyl)benzoic acid methyl ester; Methyl 5-bromo-2-fluoro-α,α,α-trifluoro-p-toluate; Benzoic acid, 5-bromo-2-fluoro-4-(trifluoromethyl)-, methyl ester; 2007915-72-0; Methyl 5-bromo-2-fluoro-4-trifluoromethylbenzoate
EINECS	Contact for details

Quality Control

Every batch of Methyl 5-Bromo-2-Fluoro-4-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical purity and lot-to-lot consistency to meet the stringent requirements of research and process development. A detailed Certificate of Analysis (COA) is provided with each shipment, typically including data from HPLC, GC, NMR (1H, 13C, 19F), and mass spectrometry for full structural confirmation and purity assessment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.