Description

3,5-Bis(Trifluoromethyl)Phenyl-Di(3-Nitrophenyl)Phosphine Oxide is a specialized organophosphorus compound featuring a phosphine oxide core flanked by electron-deficient aromatic rings, making it a valuable ligand and building block in advanced chemical synthesis. Its unique structure, combining trifluoromethyl and nitro substituents, is engineered to impart high electron-withdrawing character and thermal stability, which is critical for demanding catalytic and materials science applications. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries who require precise control over reaction pathways and material properties.

Application

• Catalysis: Serves as a sophisticated ligand for transition metal catalysts in cross-coupling reactions (e.g., Suzuki, Heck) due to its strong electron-withdrawing nature, enhancing catalytic activity and selectivity.
• Pharmaceutical Intermediates: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated or nitrated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the introduction of trifluoromethyl and nitro groups can significantly alter bioactivity and environmental stability.
• Materials Science: Incorporated as a monomer or additive in high-performance polymers and resins to improve flame retardancy, thermal stability, and optical properties.
• Organic Electronics: Investigated as a component in electron-transport materials (ETMs) or host materials for organic light-emitting diodes (OLEDs) and perovskite solar cells.
• Chemical Research: A valuable reagent for academic and industrial R&D in organometallic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenyl-Di(3-Nitrophenyl)Phosphine Oxide
CAS No.	299176-63-9
Molecular Formula	C21H11F6N2O5P
Molecular Weight	516.29 g/mol
Synonyms	Bis(3-nitrophenyl)[3,5-bis(trifluoromethyl)phenyl]phosphine oxide; [3,5-Bis(trifluoromethyl)phenyl]bis(3-nitrophenyl)phosphine oxide; Di(3-nitrophenyl)[3,5-bis(trifluoromethyl)phenyl]phosphine oxide; Phosphine oxide, P-[3,5-bis(trifluoromethyl)phenyl]-P,P-bis(3-nitrophenyl)-; (3,5-Bis(trifluoromethyl)phenyl)bis(3-nitrophenyl)phosphine oxide
EINECS	Contact for details

Quality Control

Our production of 3,5-Bis(Trifluoromethyl)Phenyl-Di(3-Nitrophenyl)Phosphine Oxide adheres to a stringent quality management system to ensure batch-to-batch consistency and high purity for critical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assay, NMR for structural confirmation, and ICP-MS for trace metal analysis. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to prevent degradation. Keep away from strong oxidizers and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.