Description

Avosentan is a potent and selective endothelin A (ETA) receptor antagonist, a key compound in advanced pharmaceutical research. Its primary value lies in its targeted mechanism of action, which has been investigated for the treatment of conditions involving endothelin system dysregulation, such as diabetic nephropathy and certain cardiovascular disorders. This high-purity compound is essential for research institutions, pharmaceutical developers, and contract research organizations (CROs) engaged in preclinical studies and novel drug discovery programs.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of endothelin receptor antagonist therapies.
• Preclinical Studies: Used in in vitro and in vivo models to study the pathophysiological role of endothelin-1 and evaluate therapeutic efficacy.
• Mechanism of Action (MoA) Investigation: A vital tool for elucidating the ETA receptor signaling pathway and its implications in renal and cardiovascular diseases.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to identify and characterize new drug candidates.
• Academic Research: Supports fundamental biomedical research in university and institutional laboratories focusing on endothelin biology.

Basic Information

Product Name	Avosentan
CAS No.	290815-26-8
Molecular Formula	C29H38N2O6S
Molecular Weight	542.69 g/mol
Synonyms	SPP301; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid; 5-Isopropyl-2-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}pyridazin-3(2H)-one; Avosentan hydrate; SPP 301; SPP-301
EINECS	Contact for details

Quality Control

Our Avosentan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities <2.0%
Water Content (KF)	<0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.