Description

(R)-4-Benzyl-3-(3-Cyclopropyl-Propionyl)-Oxazolidin-2-One CAS NO 289677-11-8 is a high-purity, chiral oxazolidinone derivative widely recognized as a versatile chiral auxiliary and building block in asymmetric synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, ensuring high enantiomeric excess in critical synthetic steps. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Employed for the enantioselective alkylation, aldol, and Diels-Alder reactions to install stereocenters with high fidelity.
• Pharmaceutical Intermediate: A key building block in the research-scale and process development of novel therapeutic agents, including potential CNS and antiviral drugs.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial manufacturing of chiral APIs.
• Academic & Institutional Research: Serves as a critical reagent in methodological studies and the development of new catalytic systems in university and R&D laboratory settings.
• Fine Chemical Production: Integral to the synthesis of specialty chemicals, flavors, and fragrances where specific chirality is required.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(R)-4-Benzyl-3-(3-Cyclopropyl-Propionyl)-Oxazolidin-2-One
CAS No.	289677-11-8
Molecular Formula	C16H19NO3
Molecular Weight	273.33 g/mol
Synonyms	(R)-4-Benzyl-3-(3-cyclopropylpropanoyl)oxazolidin-2-one; (R)-4-Benzyl-3-(3-cyclopropylpropionyl)-2-oxazolidinone; (R)-N-[(Benzyloxy)carbonyl]-3-cyclopropylpropionamide cyclic derivative; Evans Auxiliary derivative; (R)-3-(3-Cyclopropylpropionyl)-4-benzyl-2-oxazolidinone; (R)-4-Benzyl-3-(3-cyclopropanepropionyl)oxazolidin-2-one; (R)-N-Benzyloxycarbonyl-3-cyclopropylpropionamide oxazolidinone
EINECS	Contact for details

Quality Control

Our (R)-4-Benzyl-3-(3-Cyclopropyl-Propionyl)-Oxazolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.